Remote Sensing, Free Full-Text
Frontiers Mitochondrial quality control in health and cardiovascular diseases
Ion channels are membrane-spanning integral proteins expressed in multiple organs, including the eye. In the eye, ion channels are involved in various physiological processes, like signal transmission and visual processing. A wide range of mutations have been reported in the corresponding genes and their interacting subunit coding genes, which contribute significantly to an array of blindness, termed ocular channelopathies. These mutations result in either a loss- or gain-of channel functions affecting the structure, assembly, trafficking, and localization of channel proteins. A dominant-negative effect is caused in a few channels formed by the assembly of several subunits that exist as homo- or heteromeric proteins. Here, we review the role of different mutations in switching a “sensing” ion channel to “non-sensing,” leading to ocular channelopathies like Leber’s congenital amaurosis 16 (LCA16), cone dystrophy, congenital stationary night blindness (CSNB), achromatopsia, bestrophinopathies, retinitis pigmentosa, etc. We also discuss the various in vitro and in vivo disease models available to investigate the impact of mutations on channel properties, to dissect the disease mechanism, and understand the pathophysiology. Innovating the potential pharmacological and therapeutic approaches and their efficient delivery to the eye for reversing a “non-sensing” channel to “sensing” would be life-changing.
IJMS, Free Full-Text
Robbie Robertson - Wikipedia
Orai1, the Ca2+-selective pore in the plasma membrane, is one of the key components of the Ca2+release-activated Ca2+ (CRAC) channel complex. Activated by the Ca2+ sensor in the endoplasmic reticulum (ER) membrane, stromal interaction molecule 1 (STIM1), via direct interaction when ER luminal Ca2+ levels recede, Orai1 helps to maintain Ca2+ homeostasis within a cell. It has already been proven that the C-terminus of Orai1 is indispensable for channel activation. However, there is strong evidence that for CRAC channels to function properly and maintain all typical hallmarks, such as selectivity and reversal potential, additional parts of Orai1 are needed. In this review, we focus on these sites apart from the C-terminus; namely, the second loop and N-terminus of Orai1 and on their multifaceted role in the functioning of CRAC channels.
Cells, Free Full-Text
A comprehensive ranking of all 156 players in the 151st Open Championship field at Royal Liverpool.
Ranking the entire 151st Open field, from No. 1 to No. 156
Structural characterization of tin in toothpaste by dynamic nuclear polarization enhanced 119Sn solid-state NMR spectroscopy
Ursula von der Leyen - Wikipedia
Empire State Building - Wikipedia
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal
Frontiers BK Channel Gating Mechanisms: Progresses Toward a Better Understanding of Variants Linked Neurological Diseases
Hamilton, Adams, Jefferson
Once a hip indie enclave, the street went upmarket when high-end chains moved in. Then they left.
A retail story: How LA's Robertson Boulevard went from paparazzi heaven to vacant stores - Marketplace